منابع مشابه
Neurogenic Orthostatic Hypotension
n engl j med 358;6 www.nejm.org february 7, 2008 615 A 65-year-old man reports a 6-month history of dizziness, light-headedness, weakness, and fatigue while upright. He takes no medication and has no personal or family history of neurologic disease. On physical examination, his supine blood pressure is 160/100 mm Hg, with a heart rate of 72 beats per minute; on standing, his blood pressure fall...
متن کاملDroxidopa for neurogenic orthostatic hypotension
OBJECTIVE To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa dose optimization (100-600 mg 3 times daily), followed, in responders, by 7-...
متن کاملManagement of neurogenic orthostatic hypotension: an update.
Orthostatic hypotension (OH) is common in elderly people and in patients with disorders such as diabetes and Parkinson's disease. Grading of the severity of OH and its effect on the patient's quality of life are important. The symptoms vary with orthostatic stress, and subtle symptoms such as tiredness and cognitive impairment should be recognised. Standard drug treatment for OH is effective bu...
متن کاملNeurogenic orthostatic hypotension: a pathophysiological approach.
Orthostatic hypotension (OH) is defined as a persistent, consistent, orthostatic fall in systolic blood pressure of 20 mm Hg or diastolic pressure of 10 mm Hg by 3 minutes of standing up.1 Acute, unexpected, episodic falls in blood pressure while standing, as in neurocardiogenic syncope, do not satisfy criteria for OH. Medical records for 0.4% of all hospitalizations in the United States includ...
متن کاملNorepinephrine precursor therapy in neurogenic orthostatic hypotension.
BACKGROUND In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture. METHODS AND RESULTS We determined the effect of oral administration of the synthetic amino acid L-threo-3,4-dihydroxyphenylserine (L-DOPS), which is decarbo...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1970
ISSN: 0022-3050
DOI: 10.1136/jnnp.33.3.363